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A Natural Look That Lasts

Radiesse is a synthetic, injectable cohesive implant that is a blend of tiny spherical particles of synthetic calcium hydroxylapatite (CaHA) and an aqueous gel carrier. Calcium hydroxylapatite is a dense calcium-phosphate compound found naturally in human bone and teeth. In Radiesse these smooth, non-porous, consistently-shaped CaHA microsphere particles (25 – 45µm) are suspended in a carboxymethylcellulose gel carrier.

The primary compound used in Radiesse is pure, synthetic calcium hydroxylapatite particles composed of calcium and phosphate ions. Because these occur naturally in the body, they are inherently biocompatible. Identical in composition to the mineral portion of human bone, these microparticles will slowly dissolve and be metabolized in the same way as endogenous bone fragments from common fractures. CaHA has been used for decades in plastic and reconstructive surgery, orthopedics, otology, ENT, otolaryngology, maxillofacial surgery, neurosurgery, dentistry, and urology. The gel carrier is comprised of cellulose, glycerin and sterile water; all of which are biocompatible and classified as Generally Recognized as Safe (GRAS) by the FDA and are listed in the United States Pharmacopoeia (USP) and British Pharmacopoeia (BP).

Radiesse provides volume by its physical presence, and studies demonstrate a well-defined tissue matrix forms around and throughout the CaHA implant particles identical to the surrounding area. The implant site remains soft and flexible, similar to the surrounding tissue, and does not show any evidence of ossification, calcification, or migration. Areas injected more than once demonstrated similar tissue response and infiltration results as those sites injected only once. Radiesse seems to have a bit more body or substance, and on a volume per volume basis may give more ‘fill’ than an HA product. This means that for most areas you can obtain the same results with either type of filler product, but you will need to use more HA than Radiesse.

Because no derivative of human or animal tissue is used in Radiesse, there is assurance that no human or animal disease can be contracted from the implant material. The synthetic formulation of the CaHA particles and the use of other biocompatible ingredients also removes any need for patient sensitization skin testing, allowing immediate treatment.

Radiesse dermal filler is now FDA approved for the correction of moderate to severe facial folds and wrinkles around the nose and mouth, including Nasolabial Folds. The FDA trial compared Radiesse to CosmoPlast, a common human collagen-based dermal filler, in a split-face, multi-site study. At all time points, Radiesse demonstrated clear superiority with over 82% of respondents reporting improvement, while only 27% reported clear improvement with CosmoPlast. Radiesse is also FDA approved for the treatment of facial lipoatrophy, the significant loss of fat underneath the skin, which can cause indentations, sunken cheeks and hollow eyes. Radiesse® fills and volumizes to correct the signs of facial fat loss and restore a natural, youthful look. Other FDA approval involves the use of Radiesse for use in correcting oral maxillofacial defects, vocal fold insufficiency, and radiographic tissue marking.

According to The American Society for Aesthetic Plastic Surgery, 77,067 Radiesse treatments were performed in the US in 2006; this is a 90% increase from the previous year.

Radiesse® Treatment

Radiesse is injected just beneath the skin in tiny amounts with a fine (27ga) needle. The result is instantaneous and produces a long-lasting, natural enhancement, for your skin. The injected microspheres produce a strong, long-lasting foundation within a matrix that allows cellular infiltration and collagen production. This tissue ingrowth lifts the tissue and smoothes out wrinkles. Radiesse is the heaviest of the facial fillers, and is recommended to improve deeper creases such as the nasolabial folds, marionette lines, and the pre-jowl sulcus; it also works well to fill in hollow temples, enhance fullness of the cheeks, improve the contour of the chin and the jawline, and to soften nasal defects.

A significant component of facial aging results from fat atrophy, and to a lesser extent boney resorption, with subsequent facial volume loss, skin laxity, drooping and wrinkle formation. The characteristics of Radiesse allow the treatment focus to be on “volume restoration”, instead of just on filling in a line here or there. Radiesse works extremely well for restoring volume to the midface. Skilled placement of the product restores volume to the cheeks, improves the transition of the lower eyelid-cheek junction, enhances malar (cheek) prominence, and can be used to restore cheek bone prominence and facial width. This “volume” approach provides superior results because it improves fullness and contour, addressing one of the principle causes of facial aging rather than just its effects.

The resulting structure of CaHA and natural tissue forms a cohesive implant that remains in place for many months; Radiesse lasts on average about 12 months. The extremely slow, natural process of CaHA degradation provides augmentation durability, as well as a safe, ultimate outcome of the implant. Some patients may require a small touch-up procedure after absorption of the gel carrier.radiesse_pic1 radiesse_pic2 radiesse_pic3 radiesse_pic4